Massive hyperdiploidy and tetraploidy are rare in AML.

2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Massive hyperdiploidy and tetraploidy define a prognostically unfavorable cytogenetic group in de novo acute myelocytic leukemia (AML).

According to published research from the United States, "Massive hyperdiploidy (>50 chromosomes) and tetraploidy (4n) are rare cytogenetic abnormalities in myelocytic malignancies, and their significance is unknown."

"We report on 11 patients with AML and 2 patients with a myelodysplastic syndrome (MDS) with massive hyperdiploidy (10 patients) or tetraploidy (3 patients) seen at our institution over a 12-year period," wrote R.V. Iyer and colleagues, Roswell Park Cancer Institute, …